Effects of Age on Lipoprotein Associated Phospholipase A2, Heart Type Fatty Acid Binding Protein, and Soluble Suppression of Tumorigenesis-2 in Chronic Heart Failure Assessment

Background: There is impairment in cardiac structure and function which could cause the release of some myocardial biomarkers and subsequently lead to increased susceptibility to heart failure during aging. Objectives: This study aimed to determine the effects of age on LP-PLA2, sST2 and H-FABP in chronic heart failure assessment. Methods: This was a case-control study where a total of 180 subjects (aged 30-80) years consisting of 100 subjects with chronic heart failure (test) and 80 apparently healthy (control) subjects were recruited through a convenient sampling technique. Five milliliter of blood was collected from each participant and their serum sST2, H-FABP, and LP-PLA2 were measured using ELISA technique. Independent student T test was carried out to check for any statistical difference between the study groups. One-way ANOVA and post hoc were done to check for statistical difference among and between groups. Level of significance was taken at P<0.05. Results: Our result showed that the serum levels of sST2, H-FABP, and Lp-PLA2 were significantly elevated in CHF when compared with control subjects (p=0.000, p=0.000 and p=0.000) respectively. H-FABP and sST2 were significantly raised in CHF subjects aged between 60 years and above (p<0.05). In the control subjects, there was no significant difference in the studied biomarkers among and between the age groups. Conclusions: Lp-PLA2, H-FABP, and sST2 were higher in CHF subjects, H-FABP and sST2 were raised among the CHF ≥60years. Therefore, they could be better markers in the assessment of chronic heart failure in the elderly.