Neuromodulation-assisted Ego-disengagement: the NEURO-EGO Study Stage 2

This study is being done to evaluate the relative effectiveness of distinct types ofnon‐invasive brain stimulation ‐ NIBS (TES‐TI and TES) on subjective ego disengagementand cortical activity in experienced meditators and meditation naïve healthy adults.Stage 1a was designed to establish the optimal level of stimulation to achieve egodisplacement in experienced meditators. Stage 1b used the level of stimulationestablished in 1a to discern the region of the posteromedial cortex (PMC) wheredisruption is most effective in achieving ego displacement in experienced meditators.This stage, stage 2 will use the most effective stimulation and PMC parameters tomeditation naïve healthy adults.Primary Objective (stage 2):‐ To evaluate the effectiveness of NIBS on ego disengagement and cortical activity inmeditation naïve healthy adults acutely and longitudinallySecondary Objectives (stage 2): ‐ Evaluate the relationships between NIBS, ego‐disengagement, and trait assessmentsopenness and wellbeing ‐ Evaluate the effect of the use of topical anesthetics on the EEG response evoked byNIBS