Comparison of intravenous and nebulised routes of dexmedetomidine as premedication on surgical field visualisation in functional endoscopic sinus surgeries : a randomised control trial

INTERVENTION: Intervention1: Intravenous Dexmedetomidine as premedication: dexmedetomidine at a dose of 1 microgram/ kilogram diluted in 100 ml normal saline once via intravenous route for 15 minutes over infusion prior to induction of anaesthesia Intervention2: Nebulised Dexmedetomidine as premedication: dexmedetomidine at a dose of 1 microgram/ kilogram diluted in 5 ml normal saline once via nebulisation route for 15 minutes over infusion prior to induction of anaesthesia Control Intervention1: Intravenous Normal saline and Nebulisation with Normal saline: Intravenous Normal saline 100ml and Nebulisation with normal saline 5 ml as premedication prior to induction of anaesthesia CONDITION: Health Condition 1: J01‐ Acute sinusitis Health Condition 2: J31‐ Chronic rhinitis, nasopharyngitisand pharyngitis Health Condition 3: J32‐ Chronic sinusitis Health Condition 4: O‐ Medical and Surgical Health Condition 5: J33‐ Nasal polyp Health Condition 6: J34‐ Other and unspecified disorders ofnose and nasal sinuses Health Condition 7: J30‐ Vasomotor and allergic rhinitis PRIMARY OUTCOME: Surgical field visualisationTimepoint: till the end of surgery SECONDARY OUTCOME: Hemodynamic changes, post‐operative sore throat, post‐ ; operative nausea & vomiting and sedative effect will be observedTimepoint: till 24 hours after ; ; the end of the surgery. INCLUSION CRITERIA: American society of anaesthesiologists physical status 1 to 2 scheduled for elective functional endosocopic sinus surgeries under general anaesthesia