How Fig Polyphenols Affect Blood Sugar and Insulin Levels After Eating in Adults at Risk for Diabetes

Recruited subjects must meet all eligibility criteria, sign and date a writtenInstitutional Review Board (IRB)‐approved Informed Consent Form.The trial will test 2 dietary conditions which will be either the equivalent of oneserving of dried California Mission Figs (40 g, 120 kcal) or a calorie‐matched controlmeal.Pre‐Screening: To learn more about the study and to pre‐qualify, potential subjects cancall the CNRC or visit the website posted on recruitment flyers or from other recruitmentmaterials. If they call the CNRC, a staff member will provide a brief background on thestudy and ask a series of questions from a pre‐screening questionnaire to see if they maybe eligible to participate. The same questionnaire is available on the website and can befilled out by potential subjects online. The pre‐screening questionnaire includesself‐reported information about health status and lifestyle factors that can be used todetermine if someone is not eligible for the study.Information Session and Screening Session: Information Session and Screening Visit mayoccur simultaneously, or Information Session may occur prior to Screening Visit. Prior tothe Screening Visit, potential subjects will be asked to arrive at the CNRC after anovernight‐fast (stop eating after 10 pm) and be well‐hydrated. Subjects should aim fordrinking at least 8‐10 cups of water the 24 h prior to the Screening Visit.Information Session: At the CNRC, pre‐screened subjects will participate in anInformation Session where they will be informed of all study procedures and studyschedules. If willing to adhere to all study procedures and schedules, they will be askedto read, ask questions, sign and date the Institutional Review Board (IRB) approvedInformed Consent Form (ICF) before any laboratory or study screening procedures begin.Screening Visit: After meeting eligibility criteria for blood glucose (BG) and bloodpressure (BP) measures, subjects will advance to further screening procedures which willinclude anthropometric measurements (height, weight, waist circumference, bodycomposition), BMI (calculated from height and weight), medical history, prior andconcomitant medication, and dietary supplements use, and completion of a series ofquestionnaires relating to their general health and lifestyle. Woman under the age of 60year, will be required to take a pregnancy test.Pre‐Study Visit: If the subject is qualified based on the screening results, thePre‐Study visit will take place immediately after the screening or on a later date. Thisvisit lasts approximately 30‐45 minutes, during which the subject will meet with one ofthe investigators who will provide detailed instructions on the study procedures and howto prepare for each study day. They will also receive training on study procedures,including dietary restrictions, medications and supplements to avoid, food recording, andovernight fasting requirements. The study dates will be scheduled, and they will receivea study booklet containing the study calendar and all the instructions covered during thePre‐Study visit.Test Day Visits: The study is of two weeks with each visit having a follow up visit for a24 hr blood draw. We will collect the three‐day food record and verify that the subjectshave fasted overnight, consumed a standardized dinner meal, avoided the specified fooditems, had sufficient sleep, and maintained dietary and exercise patterns consistent withthe study procedures. Once everything is confirmed, we will measure their weight, bodycomposition, vital signs (blood pressure, heart rate, and forehead temperature), andcheck their fasting blood glucose with a finger prick test. The visits include bloodcollection, urine collection, filling of the Online Dietary Questionnaire (ASA24) and GItract diary. During each of the two study visits, blood will be collected eight times pervisit, with a total of 120 mL of blood collected and four urine collection throughout thestudy across all visits.