The effect of a substance in Green tea in the decrease of compounds formed in the food preparation process that affect human health

INTERVENTION: B01.650.940.800.575.100.928.500.500.500 D10.212.302 Dietary supplement The study was a randomized, double‐blind, placebo‐controlled, crossover clinical trial with 16 ( all the women participate in both groups ‐ placebo and intervention) healthy young women, 18 to 25 years of age. The HFAGE (High fat, high AGE) assays were performed with a washout period of one week. Intervention group: high fat diet and AGE (Advanced glycation end products) + 800 mg EGCG (Eppigalocatechin‐3‐galate) divided into 2 400 mg supplementation capsules given immediately prior to the ingestion of HFAGE (High fat, high AGE). Placebo group: high fat diet and AGE (Advanced glycation end products) + 800 mg of corn starch divided into 2 capsules of 400 mg supplementation given immediately prior to ingestion of HFAGE (High fat, high AGE). Blood samples and blood pressure were collected shortly before the intervention, 90 and 120 min after the end of HFAGE ingestion. Carboxymethyl lysine (CML) was the compound chosen for the measurement of AGE. HFAGE consisted of 80 g of McDonald's potatoes containing 1217.60 kU CML, 130 g of fried bacon for 5 minutes without addition of oil, containing 119,050.10 kU CML and 60 g of grated Parmesan cheese containing 10 140 kU of LMC, totaling 130,407.70 kU CML. CONDITION: D04.210.500.247.808.197.225 I01.880.787.839.500 M01.975 Prevention of the ills caused by the ingestion of fat and advanced glycation end products (AGEs) in healthy women. ; D04.210.500.247.808.197.225 ; I01.880.787.839.500 ; M01.975 PRIMARY OUTCOME: The expected outcome for the present study is 10% reduction in advanced glycation end products (AGE), measured by serum carboxymethyl lysine, and triglycerides concentrations 120 minutes after epigallocatechin‐3‐gallate administration and AGE‐rich meal intake. SECONDARY OUTCOME: A reduction in insulin resistance (5%) is expected after (120 min) the epigallocatechin‐3‐gallate administration and AGE‐rich meal intake. An improvement in insulin resistance (5%) is expected after (120 min) the epigallocatechin‐3‐gallate administration and AGE‐rich meal intake. INCLUSION CRITERIA: Female; healthy; eutrophic (BMI between 18.5 kg / m2 and 24.9 kg / m2) and age between 18 and 25 years.