The Swinburne Multivitamin Study: The Effects of Multivitamin Supplementation on mood, stress and brain function in older adults

INTERVENTION: The current study compares multivitamin supplementation to a placebo. Participants are instructed to take one tablet daily with food, for a period of 16 weeks. Swisse Women's Ulitivite 50+ V One tablet per day for 16 weeks. RETINYL ACETATE (equiv. to 2500 IU of vitamin A) 862.5 mcg d‐ALPHA‐TOCOPHERYL ACID SUCCINATE (equiv. vitamin E 24.2 IU) 20 mg THIAMINE HYDROCHLORIDE (vitamin B1) 30 mg RIBOFLAVINE (vitamin B2) 30 mg NICOTINAMIDE (vitamin B3) 20 mg CALCIUM PANTOTHENATE (vitamin B5) (equiv. pantothenic acid 64.13mg) 70 mg PYRIDOXINE HYDROCHLORIDE (vitamin B6) (equiv. pyridoxine 24.68mg) 30 mg CYANOCOBALAMIN (vitamin B12) 115 mcg CHOLECALCIFEROL (vitamin D3) (equiv. vitamin D 200 IU) 5mcg BIOTIN (vitamin H) 150 mcg FOLIC ACID 500 mcg CALCIUM ASCORBATE DIHYDRATE (vitamin C)(equiv. ascorbic acid 165.3mg) 200 mg PHYTOMENADIONE (vitamin K1) 60 mcg CITRUS BIOFLAVONOIDS EXTRACT 20 mg CALCIUM OROTATE (equiv. calcium 10mg) 100 mg MAGNESIUM ASPARTATE DIHYDRATE (equiv. magnesium 6.74mg) 100 mg SELENOMETHIONINE (equiv. selenium 26mcg) 65 mcg MOLYBDENUM TRIOXIDE (equiv. molybdenum 45mcg) 67.5 mcg CHROMIUM PICOLINATE (equiv. chromium 50 mcg) 402 mcg MANGANESE AMINO ACID CHELATE (equiv. manganese 3mg) 30 mg FERROUS FUMERATE (equiv. iron 5mg) 16.01 mg COPPER GLUCONATE (equiv. copper 1.2mg) 8.57 mg POTASSIUM IODIDE (equiv. iodine 149.83mcg) (equiv. potassium 46.18mcg) 196 mcg ZINC AMINO ACID CHELATE (equiv. zinc 15mg) 75 mg Lactobacillius rhamnosus 80 million organisms Lactobacillus acidophilus 80 million organisms Bifidobacterium longum 35 million organisms VACCINIUM MACROCARPON FRUIT DRY (patented cranberry PACRAN) 800 mg SILYBUM MARIANUM DRY FRUIT (St. Mary’s thistle) (equiv. flavanolignans calculated as silybin 17.14mg) 1500 mg GINKGO BILOBA LEAF DRY (Maidenhair tree) (equiv. Ginkgo flavonglycosides 4.8mg and ginkgolides and bilobalide 1.2mg) 1000 mg TUNERA DIFFUSA LEAF DRY (Damiana) 500 mg SCUTELLARIA LATERIFLORA HERB DRY (Skullcap) 50 mg VITIS VINIFERA DRY SEED (Grape seed) (equiv. procyanidins 7.9mg) 1000 mg URTICA DIOICA LEAF DRY (Nettle) 100 mg UBIDECARENONE (Co‐enzyme Q10) (from patented Ultrasome CoQ10) 2 mg CYNARA SCOLYMUS LEAF DRY (Globe artichoke) 50 mg CIMICIFUGA RACEMOSA ROOT & RHIZOME DRY (Black cohosh) 200 mg CURCUMA LONGA RHIZOME DRY (Tumeric) 100 mg WITHANIA SOMNIFERA ROOT DRY (Ashwagandha) 500 mg CRATAEGUS MONOGYNA FRUIT DRY (Hawthorn) 100 mg SILICA COLLOIDAL ANHYDROUS (equiv. silicon 9.35mg) 20 mg BACOPA MONNIERI WHOLE PLANT DRY (Bacopa) (equiv. bacosides calculated as bacoside A 1.125mg) 50 mg LECITHIN POWDER – SOY PHOSPHATIDYLSERINE ENRICHED SOY (equiv. phosphatidylserine 2mg) 10 mg SPEARMINT OIL 2 mg VACCINIUM MYRTILLUS FRUIT DRY (Bilberry) (equiv. anthocyanosides 324mcg) 100 mg TAGETES ERECTA FLOWER DRY (Marigold) (Lutein esters calculated as lutein (of Tagetes erecta) 1mg) 100 mg Swisse Men's Ultivite 50+ V Multivitamin, mineral and herbal supplementation. One tablet per day for 16 weeks. Swisse Men's Ultivite 50+ V RETINYL ACETATE (equiv. to 2500 IU of vitamin A) 862.5 mcg d‐ALPHA‐TOCOPHERYL ACID SUCCINATE (equiv. vitamin E 30.25 IU) 25 mg THIAMINE HYDROCHLORIDE (vitamin B1) 35 mg RIBOFLAVINE (vitamin B2) 35 mg NICOTINAMIDE (vitamin B3) 25 mg CALCIUM PANTOTHENATE (vitamin B5) (equiv. pantothenic acid 68.7mg) 75 mg PYRIDOXINE HYDROCHLORIDE (vitamin B6) (equiv. pyridoxine 20.56mg) 25 mg CYANOCOBALAMIN (vitamin B12) 120 mcg CHOLECALCIFEROL (vitamin D3) (equiv. vitamin D 200 IU) 5mcg BIOTIN (vitamin H) 200 mcg FOLIC ACID 500 mcg CALCIUM ASCORBATE DIHYDRATE (vitamin C) (equiv. ascorbic acid 165.3mg) 200 mg PHYTOMENADIONE (vitamin K) 70 mcg CITRUS BIOFLAVONOIDS EXTRACT 20 mg CALCIUM OROTATE (equiv. calcium 10mg) 100 mg MAGNESIUM ASPARTATE DIHYDRATE (equiv. magnesium 6.74mg) 100 mg SELENOMETHIONINE (equiv. selenium 26mcg) 65 mcg MOLYBDENUM TRIOXIDE (equiv. molybdenum 45mcg) 67.5 mcg CHROMIUM PICOLINATE (equiv. chromium 50 mcg) 402 mcg MANGANESE AMINO ACID CHELATE (equiv. manganese 4mg) 40 mg FERROUS FUMERATE (equiv. iron 5mg) 16.01 mg COPPER GLUCONATE (equiv. copper 1.7mg) 12.14 mg POTASSIUM IODIDE (equiv. iodine 149.83mcg) (equiv. potassium 46.18mcg) 196 mcg ZINC AMINO ACID CHELATE (equiv. zinc 20mg) 100 mg Lactobacillius rhamnosus 80 million organisms Lactobacillus acidophilus 80 million organisms Bifidobacterium longum 35 million organisms VACCINIUM MACROCARPON FRUIT DRY (patented cranberry PACRAN) 1000 mg SILYBUM MARIANUM DRY FRUIT (St. Mary’s thistle) (equiv. flavanolignans calculated as silybin 19.43mg) 1700 mg GINKGO BILOBA LEAF DRY (Maidenhair tree) (equiv. Ginkgo flavonglycosides 4.8mg and ginkgolides and bilobalide 1.2mg) 1000 mg TRIBULUS TERRESTRIS FRUIT & ROOT DRY (Tribulus) 1000 mg DULACIA INOPIFLORA ROOT DRY (Muirapuama) 200 mg SCUTELLARIA LATERIFLORA HERB DRY (Skullcap) 50 mg VITIS VINIFERA DRY SEED (Grape seed) (equiv. procyanidins 7.9mg) 1000 mg SERENOA REPENS FRUIT DRY (Saw palmetto) CONDITION: Influence of nutrients on mood and stress in healthy older adults Investigate the role of cardiovascular system in relation to mood and stress PRIMARY OUTCOME: patterns of brain electrical activity using the steady state visual evoked potential technique Scores on mood and stress scales. These scales include: ; ‐Beck Depression Inventory (BDI) ; ‐Beck Anxiety Inventory (BAI) ; ‐The Depression, Anxiety, Stress Scale (DASS) ; ‐The Perceived Stress Scale (PSS) ; ‐The Hospital Depression and Anxiety Scale (HADS) Stress/mood using multitasking battery to induce stress and mood questionnaires before and after stress task. The questionnaires include ; ‐Bond Lader Visual Analogue Scales ; ‐The State/Trait anxiety Index (STAI) ; ‐The NASA‐task load index (After task only) SECONDARY OUTCOME: Blood levels of: homocysteine; c‐reactive protein; fibrinogen; lipids; vitamins B6, B12, E, zinc and folate; electrolytes; telomere length. Cardiovascular function using transcranial doppler ultrasound and arterial stiffness measure (using sphygmocor system) INCLUSION CRITERIA: ‐Right‐handed ‐free from psychiatric disorders ‐Must not be taking anticoagulants, antidepressants, antipsychotics, anxiolytics, acetylcholine esterase (AChE) inhibitors, anti‐Parkinson’s medication, illicit drugs or any cognitive enhancing drugs ‐must not be taking any vitamin/mineral or herbal supplements ‐non‐smoker