Relationships among Lymphocyte Subsets, Cytokines, and the Pulmonary Inflammation Index in Coronavirus (COVID-19) Infected Patients.

We explored the relationships between lymphocyte subsets, cytokines, pulmonary inflammation index (PPI), and disease evolution in patients with COVID-19. A total of 123 patients with COVID-19 were divided into mild and severe groups. Lymphocyte subsets and cytokines were detected on the first day of hospital admission and lung CT results were quantified by PII. Difference analysis and correlation analysis were performed on the two groups. A total of 102 mild and 21 severe patients were included in the analysis. There were significant differences in CD4+ T, CD8+ T, IL-6, IL-10 and PII between the two groups. Significant positive correlations between CD4+ T and CD8+ T, IL-6 and IL-10 were observed in the mild group (r2 = 0.694, r2 = 0.633; P < 0.01). After "five-in-one" treatment, all patients were discharged with the exception of the four that died. Higher survival rates were obtained in the mild group and IL-6 within the normal group. CD4+ T, CD8+ T, IL-6, IL-10 and PPI can be used as indicators of disease evolution, and PPI can be used as an independent indicator for the disease evolution of COVID-19.