A randomized controlled study of aspirin combined with and without clopidogrel in postoperative antiplatelet therapy after patent foramen ovale closure

INTERVENTION: Trial group:take aspirin;Control group:take aspirin with clopidogrel; CONDITION: patent foramen ovale PRIMARY OUTCOME: Thrombosis rate on the surface of the blocker at 1 and 6 months postoperatively;Incidence of ischaemic stroke at 1 and 6 months postoperatively;Incidence of myocardial infarction at 1 and 6 months postoperatively;Incidence of bleeding events at BARC 2, 3, and 5 at 1 and 6 months postoperatively;Incidence of all‐cause mortality at 1 and 6 months post‐operatively; SECONDARY OUTCOME: Incidence of atrial fibrillation at 1 and 36months postoperatively;Incidence of palpitations at 1 and 6 months postoperatively;Incidence of heart failure at 1 and 6 months postoperatively;HIT‐6 scores at 1 and 6 months post‐operatively;Haemoglobin values at 1 and 6 months postoperatively;Platelet values at 1 and 6 months postoperatively;Prothrombin time and activated partial thromboplastin time at 1 and 6 months postoperatively;Incidence of BARC1 bleeding events at 1 and 6 months postoperatively;Residual shunt at 6 months postoperatively; INCLUSION CRITERIA: 1. All patients 15‐75 years of age with successful transcatheter PFO occlusion using the Amplatzer occluder; 2. No previous history of PCI surgery and no history of persistent atrial fibrillation; 3. No aspirin or other anti‐platelet aggregating drugs have been used within 1 month prior to admission;