Testing the Abuse Liability of Hyper-palatable Foods

A within‐subjects, double‐blind, randomized crossover design will be used to test theabuse liability of a commonly consumed hyper‐palatable food (HPF; potato chips) incontrolled laboratory conditions, compared to a negative (non‐HPF) control and modifieddoses (Aim 1). In alignment with FDA requirements, the study will randomize participantsto complete four study sessions in one of four mixed orders to counterbalance theordering of food stimuli across participants. One food will be assessed per session.Abuse liability tests will consist of an acute dose effects comparison to evaluatedifferences in acute rewarding effects, and a test of HPF reinforcing effects via aself‐administration task and behavioral economic food purchase task. Participants will becommunity members who report high dietary intake of potato chips (HPF stimulus in thestudy), and do not have substance use disorder or eating disorders, which may presentconfounds.