Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

INTERVENTION: investigational material(s) Generic name etc : Lysozyme hydrochloride (LYS) INN of investigational material : Therapeutic category code : 395 Enzyme preparations Dosage and Administration for Investigational material : Oral control material(s) Generic name etc : Placebo INN of investigational material : Therapeutic category code : ‐‐‐ Other Dosage and Administration for Investigational material : Oral CONDITION: Chronic Obstructive Pulmonary Disease (COPD) PRIMARY OUTCOME: Efficacy; Exacerbation of chronic obstructive pulmonary disease INCLUSION CRITERIA: Patients were eligible for inclusion in the study if they had a smoking history, a diagnosis of COPD, %FEV1< 80% and a ratio of FEV1 to forced vital capacity(FVC) of < 70%, and a documented history of at least one exacerbation leading to any treatment within the previous year.