Investigation of the effect of curcumin in Multiple Sclerosis

INTERVENTION: Intervention 1: Intervention group: Intervention group: MS patients who take Corkomine oral capsule for 3 months at a dose of 370 mg, take one a day at the beginning of the study and then take it twice a day. It has high antioxidant properties. Intervention 2: Control group: MS patients who receive placebo for 3 months. CONDITION: Multiple Sclerosis. ; Demyelinating diseases of the central nervous system SECONDARY OUTCOME: Expanded Disability Status Scale. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin capsules. Method of measurement: questionnaire. Fatigue Severity Scale. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin capsules. Method of measurement: questionnaire. Gait disorder. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the start of use of curcumin capsules. Method of measurement: 25 foot test. INCLUSION CRITERIA: The study subjects must have RRMS type Ms disease They are 18 to 50 years old and EDSS (disease incapacity severity) must be less than 4 Patients who have been diagnosed with MS for at least one year Patients who do not have a specific digestive problem (gastric and duodenal ulcers, irritable bowel syndrome, indigestion) Not sensitive to curcumin They do not receive zinc or selenium supplements Antioxidant corticosteroids, such as vitamin E‐A‐D, have not been used for at least the past two weeks. They are not pregnant Don't be a breastfeeding woman They do not have special liver or kidney problems PRIMARY OUTCOME: ?? ???????. Timepoint: Measurement of oxygenated water at the beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin capsules. Method of measurement: Oxygenated water measurement kit. Alanin amino transferase. Timepoint: The beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin. Method of measurement: Alanine Amino Transfer Measurement Kit. Aspartate amino transferase. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin. Method of measurement: Aspartate aminotransferase assay kit. Blood creatinine. Timepoint: At the beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin. Method of measurement: Creatine measuring kit. Glutathione Revival. Timepoint: Measurement of glutathione reductase at the beginning of the study (before the start of the intervention) and 3 months after the start of the use of curcumin capsules. Method of measurement: Glutathione Revitalization Measurement Kit. Malone Dialdehyde. Timepoint: Measurement of malondialdehyde at the beginning of the study (before the intervention) and 3 months after the start of use of curcumin capsules. Method of measurement: Malon dialdehyde Measurement Kit. Nitrogen in the blood urea. Timepoint: At the beginning of the study and 3 months after taking curcumin. Method of measurement: Blood urea nitrogen measurement kit. Super Oxide Dismutase. Timepoint: Measurement of dismutase superoxide at the beginning of the study (before the start of the intervention) and 3 months after the start of taking curcumin capsules. Method of measurement: Dysmotase Super Oxide Measurement Kit. Total oxidative status. Timepoint: Measurement of total oxidative status at the beginning of the study (before the start of the intervention) and 3 months after the start of use of curcumin capsules. Method of measurement: Total Oxidative Status Measurement Kit.