Homeopathic pathogenetic re-experimentation of Agaricus Muscarius and comparison with Materia Medica

Homeopathy is a therapeutic system based on the similitude principle, Systematic substance experimentation in healthy subjects allows knowing the symptoms they cause (pathogenesis). The assemblage of various pathogeneses yields homeopathic therapeutic compendia called Materia Medica, among which The Guiding Symptoms of Our Materia Medica, by Constantine Hering, remains an important reference. Objective: Evaluate the concordance between the present experimentation of a homeopathic medicine (Agaricus muscarius) and the data from a referential Materia Medica. Methods: A brief pathogenetic experimentation was performed a randomized, double-blind, placebo- -controlled cross-over trial. The medicine Agaricus muscarius was experimented as 30 CH dynamization. The experimentation lasted for 8 weeks. Symptoms were classified, graded and ordered for statistical analysis. Kolmogorov-Smirnov test was used for data normality and t-Student test and ANOVA for between-group comparison. The research was approved by the Human Beings Research Ethics Committee from the Foundation Federal University of Mato Grosso do Sul. Results: No significant differences in symptom correspondence scores were noted when participants were administered remedy vs placebo. More than half of experimentation pathogenesis symptoms had a moderate to high correspondence degree to the Materia Medica (59,4%) and a high association degree to the use of remedy (53,1%). Conclusion: Reexperimentation of Agaricus muscarius has produced symptoms mostly correspondent