Trial of Short Course Therapy in Elderly Patients with High Grade Non-Hodgkin's Lymphoma

INTERVENTION: 1. PACEBO Regimen: Adriamycin, cyclophosphamide, etoposide, vincristine, bleomycin, prednisolone and septin, cycle to be repeated every 14 days for four cycles. 2. PMitCEBO Regimen: Mitoxantrone, cyclophosphamide, etoposide, vincristine, bleomycin, prednisolone and septin, cycle to be repeated every 14 days for four cycles. CONDITION: Lymphoma (non‐Hodgkin's) ; Cancer ; Lymphoma (non‐Hodgkin's) PRIMARY OUTCOME: Not provided at time of registration SECONDARY OUTCOME: Not provided at time of registration INCLUSION CRITERIA: 1. Aged 60 to 85 years 2. Newly presenting high grade lymphoma presenting as: 2.1 Follicular lymphoma 2.2 Diffuse large cell lymphoma including immunoblastic 2.3 Diffuse mixed cell lymphoma ‐ Lymphoblastic and Burkitt's lymphoma are excluded 3. Stage IB‐IV 4. Patients must be free from any other irreversible medical condition that would drastically limit their lifespan or prohibit the use of combination chemotherapy