Influence of continuous infusion of low-dose human atrial natriuretic peptide on renal function during cardiac surgery

INTERVENTION: Perioperative administration of hANP Perioperative non‐administration of hANP CONDITION: myocardial infarction, angina, valvular disease, thoracic aortic aneurysm PRIMARY OUTCOME: mortality; complication; Incidence of postoperative acute renal failure; maximum value and percent increase of Cr. SECONDARY OUTCOME: pre‐op, 0,1,3,7 days after surgery: ANP, renin activity, angiotensin II, aldosterone, blood urea nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U‐Na), urinary Cr (U‐Cr), and osmotic pressure (U‐osm) .; pre‐op, 0,1,3,7 days after surgery: creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index. INCLUSION CRITERIA: Patient undergoing cardiac surgery Patients from whom informed consent was obtained