Combined anti-inflammatory drugs for the prevention of postoperative delirium in patients undergoing coronary artery bypass grafting and the construction of a multimodal intelligent prediction model: a multicenter, prospective, open, randomized controlled study

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Group B:conventional therapy;Group A:Combination anti‐inflammatory drugs; CONDITION: Postoperativedelirium, POD PRIMARY OUTCOME: Critical Care Pain Observation Tool (CPOT);Delirium index (DELi);C‐reactive protein (CRP);Numerical rating scale (NRS);PCT Serum;Confusion Assessment Method (Short CAM);The Richmond Agitation Sedation Scale (RASS);Montreal Assessment of Cognitive Function (MoCA);IL‐6;Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index,FRAIL;Neuron‐specific enolase (NSE); SECONDARY OUTCOME: NT‐proBNP;INR;D‐DIMER;APTT; INCLUSION CRITERIA: 1. No age limited; 2. ASA class I‐III; 3. Ethical, patient voluntary participation, signed informed consent; 4. Patients admitted to extracardiac wards were assessed; 5. Select patients at high risk for delirium according to the delirium prediction probability of > 50% in the modified composite scoring formula of the delirium inde XDELi.
Epistemonikos ID: 8b6ed8f98382ff1d35fe817877730f0848d0d6f9
First added on: Oct 08, 2026