Effects of Jasminum sambac on Individuals With Non alcoholic Fatty Liver Disease's Metabolic Profiles

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2023
INTERVENTION: Intervention 1: Intervention group: 1st group (interventional group) was instructed to eat the conventional diet combined with 200 mg/kg bw/day of J.sambac in the form of salad,. Intervention 2: Control group: 2nd group (positive control) received the silymarin with 100mg/kg bw 2 times a day. Intervention 3: Control group: 3rd group (negative control) just got the conventional diet. The recommended diet, which included 20% protein, 55% carbohydrate, and 30% fat, supplied around 1500 kcal/day. CONDITION: K76.0 Nonalcoholic fatty liver disease. ; Nonalcoholic fatty liver disease PRIMARY OUTCOME: ALT(alanine transaminase), AST (aspartate aminotransferase), ALP (alkaline phosphatase) , LDH (lactate dehydrogenase). Timepoint: 3 months. Method of measurement: Venous blood samples will be taken at the start and completion of the trial. Fasting blood sugar (FBS). Timepoint: 3 months. Method of measurement: Venous blood samples willbe taken at the start and completion of the trial. Inflammation. Timepoint: 3 months. Method of measurement: Inflammation measured by check the CRP level. Platelet aggregation and platelet activation. Timepoint: 3 months. Method of measurement: Platelet aggregation was evaluated using impedance aggregometry, and platelet activation was assessed using flow cytometry. Total antioxidant capacity. Timepoint: 3 months. Method of measurement: Assessed by using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH). Total cholesterol (TC), LDL cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C). Timepoint: 3 months. Method of measurement: Venous blood samples will be taken at the start and completion of the trial and then evaluated using an enzymatic colorimetric assay utilizing commercial kits (Pars Azmoon). After apolipoprotein B‐containing lipoproteins were precipitated using chloride magnesium and dextran sulphate as part of the oxidase cholesterol technique, serum HDL and LDL cholesterol levels were measured. Triglycerides (TG). Timepoint: 3 weeks. Method of measurement: Venous blood samples will be taken at the start and completion of the trial and then evaluated using an enzymatic colorimetric assay utilizing commercial kits (Pars Azmoon). SECONDARY OUTCOME: Systolic (SBP) and diastolic blood pressure(DBP). Timepoint: 3 months. Method of measurement: Sphygmomanometer. INCLUSION CRITERIA: Participants in the study were to be 23 to 77 years old Body mass inde X>25 kg/m2 Participants diagnosed with NAFLD as determined by an ultrasound examination
Epistemonikos ID: 8b4df54306267f34a849a881966380e0e83843f5
First added on: Feb 20, 2024