Golden Rice Cookies with red betle leaf: a Tasty and Effective Biomolecular Solution for Preventing Diabetic Foot Ulcers

INTERVENTION: Experimental Dietary Supplement,Placebo Comparator Dietary Supplement Intervention group,Control group The participants will consume cookies three times a day for 28 days. The researchers will conduct follow‐up monofilament tests and random blood sugar tests on days 7, 14, and 21, and will collect samples for MMP‐9 examination on day 0 (before the intervention) and day 29 (after the intervention). Participants will be considered as dropouts if their monofilament test score increases to high risk or above, or if their random blood sugar levels are uncontrolled.,The control group will be given conventional low sugar cookies with three times a day consumption for 28 days. The researchers will conduct follow‐up monofilament tests and random blood sugar tests on days 7, 14, and 21, and will collect samples for MMP‐9 examination on day 0 (before the intervention) and day 29 (after the intervention). CONDITION: diabetic foot ulcer, complementary therapy, cookies, golden rice, piper crocatum ruiz and pav, MMP‐9 The study population consists of outpatients from wound care clinics in Makassar, Indonesia, diagnosed with Diabetes Mellitus, with increased risk neuropathy status on monofilament test examination, and ankle brachial inde Xvalue above 0.9. ; diabetic foot ulcer, complementary therapy, cookies, golden rice, piper crocatum ruiz and pav, MMP‐9 PRIMARY OUTCOME: Matrix metalloproteinase‐9 at 28 days after end of the intervention Western blotting SECONDARY OUTCOME: neuropathy score, blood glucose level day 0, 7, 14, 21, 28 at cookies consumption Michigan neuropathy instrument, one touch blood glucose, monofilament test INCLUSION CRITERIA: Patients diagnosed with Diabetes Mellitus, with increased risk neuropathy status on monofilament test examination, and ankle brachial inde Xvalue > 0.9.