EFFECT OF OZONE THERAPY ON MARGINAL BONE LEVELS AROUND DENTAL IMPLANTS

This prospective split‐mouth randomized clinical trial was conducted at the Department ofPeriodontology, Faculty of Dentistry, Adıyaman University. The study aimed to investigatewhether the application of gaseous ozone to fresh implant sockets influences marginalbone levels and bone microarchitecture following immediate implant placement. Fiftyparticipants requiring bilateral implant placement in comparable sites were enrolled. Inaccordance with the split‐mouth design, one implant site received gaseous ozone treatmentbefore implant placement, while the contralateral site served as the control, withtreatment allocation determined by computer‐generated randomization. Two participantswere lost to follow‐up, and the final analysis included 48 participants (152 implants).The primary outcome was the change in marginal bone levels after 6 months. Secondaryoutcomes included changes in bone microarchitecture assessed by fractal analysis ofstandardized radiographic images. Radiographic evaluations were performed using panoramicradiography and cone‐beam computed tomography (CBCT).