The effect of azilsartan on excercise capacity in hypertensive patients with sarcopenia

INTERVENTION: azilsartan amlodipine CONDITION: Hypertension PRIMARY OUTCOME: (1)Muscle strength of lower limbs; (2)Muscle mass of appendicular skeletal muscle.; (3)ABPM; (4)Serum concentration of angiotensin 1‐7 SECONDARY OUTCOME: Serum myokine concentration INCLUSION CRITERIA: (1) Hypertensive patients, 65yeas of age and older (2) The untreated hypertensive patients with BP beyond 140/90mmHg, or the uncontrolled hypertensive patients treated with single antihypertensive drugs other than RAS blockades (renin inhibitor, ACE inhibitor, ARB, aldosterone blocker) (3) Muscle mass of appendicular skeletal muscle measured by BIA methods less than 7.0kg//m2 in male, 5.8kg/m2 in female