Randomised, double-blind, placebo controlled study to assess efficacy of topical nicotinamide in the treatment and prevention of actinic keratosis.

INTERVENTION: Application of 1% nicotinamide lotion compared with placebo twice daily for six months. Both the active treatment and placebo will be applied topically to symmetrically distributed non‐hyperkeratotic actinic keratoses on face / scalp/ upper limbs. CONDITION: Actinic Keratoses PRIMARY OUTCOME: Reduction in total actinic keratosis count at six months compared with baseline count SECONDARY OUTCOME: Reduction in total actinic keratosis count INCLUSION CRITERIA: Symmetrically distributed non‐hyperkeratotic AKs on face / scalp/ upper limbs.Minimum of 4 AKs in one or more treatment areas.Patients have received no other treatments for AKs within the last month.