The effect of clonidine on desflurane consumption using BIS monitoring.

INTERVENTION: Trade Name: Catapres Product Name: Clonidine Product Code: N/A Pharmaceutical Form: Solution for injection INN or Proposed INN: CLONIDINE CAS Number: 4205907 Current Sponsor code: Medway NHS Trust Other descriptive name: Catapres Concentration unit: µg/ml microgram(s)/millilitre Concentration type: equal Concentration number: 150‐ Pharmaceutical form of the placebo: Solution for injection Route of administration of the placebo: Intravenous use CONDITION: Depth of anaesthesia. Consumption of volatile anaesthetic agent. ; MedDRA version: 8.1 Level: LLT Classification code 10018060 Term: General anaesthesia PRIMARY OUTCOME: Main Objective: To see if the use of intravenous clonidine, given at induction of general anaesthesia, decreases the consumption of desflurane (a routinely used volatile anaesthetic agent). Primary end point(s): Reduction in desflurane consumption. Secondary Objective: Nil INCLUSION CRITERIA: Patients having a general anaesthetic for a general surgical or orthopaedic procedure. The surgical procedure should last no longer than 2 hours. Aged between 18 and 70 years. ASA grading as 1 or 2. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range