Genomic examination and analysis for hereditary malignant tumors

INTERVENTION: Blood test for BRCA1/2 mutation CONDITION: herediraty breast and ovarian cancer, Cowden disease, Li‐fraumeni syndrome, familial adenomatous polyposis, hereditary non‐poliposis colon cancer PRIMARY OUTCOME: Efficacy of early detection program of hereditary cancers based on the results of genomic test INCLUSION CRITERIA: 1. Patients with suspected herediary malignand disease. 2. Relatives of patients with comfirmed hereditary malignant disease. 3. Healthy members of a pedigree of suspected hereditary malignant disease.