Efficacy Verification and Mechanism Exploration of AM-PAS for Improving Motor Function in Stroke Patients

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: control subjects:Sham TMS & Sham Sound;experimental group:AM‐PAS; CONDITION: stroke hemiplegia PRIMARY OUTCOME: FMA‐UE; SECONDARY OUTCOME: functional near‐infrared spectroscopy;MVC;rs‐fMRI;MEP;grip strength; INCLUSION CRITERIA: 1.Aged between 18 and 80 years, both male and female eligible; 2.First‐ever stroke confirmed by MRI or CT as unilateral stroke, with disease duration of 1‐6 months; 3.Baseline upper limb motor function: Active wrist dorsiflexion >10° ; Thumb abduction/extension >10° ; Extension >10° in at least two other fingers; 4.egree of limb impairment: Unilateral limb weakness; Fugl‐Meyer Assessment for Upper Extremity (FM‐UE) score <=54 (total score 66); 5.Absolute difference in FM‐UE scores <=2 points between two baseline assessments (7‐14 days apart); 6.Pre‐stroke modified Rankin Scale (mRS) score <=2; 7.Evokable motor evoked potentials (MEPs) in abductor pollicis brevis muscle of paretic upper limb; 8.Cognitive ability to follow instructions: Mini‐Mental State Examination (MMSE) score >=22; 9.Good tolerance to sudden auditory stimuli at 114 dB; 10.Willing to provide written informed consent;
Epistemonikos ID: 85cd1663623554338384aeaad514a40deb808983
First added on: Sep 12, 2026