Research on the Mechanism of Action of Mongolian Medicine Sand Therapy in Treating Knee Osteoarthritis Based on Metabolomics

INTERVENTION: the Mongolian Medicine Sand Therapy Group :Mongolian medicine sand therapy combined with magnetic therapy and Mongolian herbal bath intervention;Conventional Drug Group:Oral medication combined with topical patches; CONDITION: Knee Osteoarthritis PRIMARY OUTCOME: Visual Analogue Scale (VAS);Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC);Serum Differential Metabolites;Differentially expressed metabolites in Synovial Fluid; SECONDARY OUTCOME: Serum Tumor Necrosis Factor‐a(TNF‐a);Serum Interleukin‐1ß(IL‐1ß);Serum Matri XMetalloproteinase‐3 (MMP‐3); INCLUSION CRITERIA: (1) Kellgren‐Lawrence grade II–III. (2) TCM syndrome differentiation: "excessive Badagan Heyi syndrome". (3) Visual Analogue Scale (VAS) score = 4, Western Ontario and McMaster Universities Osteoarthritis Inde X(WOMAC) score = 30.