Effectiveness of Direct Current Stimulation to the head combined with Vagus Nerve Stimulation in the ear for the treatment of women with menstrual migraine

INTERVENTION: This is a randomized, open‐label, controlled clinical trial composed of two groups of women, sham and intervention. An estimated 52 participants are expected, with the study comprising an intervention group of 26 participants and a sham group also of 26 participants. Five sessions of Transcranial Direct Current Stimulation combined with Transcutaneous Vagus Nerve Stimulation will be performed, one session per week, totaling one month, 5 weeks. Evaluation, intervention, re‐evaluation, and a 180‐day follow‐up will be conducted CONDITION: G43.3 Migraine Disorders ; Complicated migraine PRIMARY OUTCOME: To assess the reduction in frequency and intensity of headaches in the intervention group compared to the sham group, using the Brief Pain Inventory and Pain Diary, considering a 2‐ point reduction in pain as a clinically significant outcome and a 50% reduction in frequency as a clinically significant outcome SECONDARY OUTCOME: No secondary outcomes are expected INCLUSION CRITERIA: Cisgender women; aged 18 to 65 years; diagnosed with Menstrual Migraine according to the 2018 criteria of The International Classification of Headache Disorders (ICHD‐3) for more than 3 months; attacks in menstruating women meeting ICHD‐3 criterion B; attacks (without treatment or with ineffective treatment) occurring exclusively on day 1 ± 2 (i.e., days ‐2 to +3) of menstruation, in at least two of three menstrual cycles; and, additionally, at other times during the cycle