Effect of Pre-emtive Pregabalin on Postoperative Pain, Deliberate Hypotension and Analgesic requirement for Patients Undergoing Dacryocystorhinostomy Surgery under Local Anesthesia.

INTERVENTION: Group I Pregabalin Oral Capsule Group II Placebo orla capsule CONDITION: ; Anaesthesia Anaesthesia PRIMARY OUTCOME: Postoperative pain was assessed using 0‐10 visual analogue score (VAS) where 0 represents no pain and 10 worst pain imaginable. Pain scores were recorded at 1, 2, 4, 8, 12, and 24h postoperative. SECONDARY OUTCOME: ‐ The total dose of nitroglycerin (mg) used for each patients. ; ‐ The quality of surgical field was also recorded using Fromm and Boezaart scale [12], where 0 grade represent no bleeding, 1 grade represent slight bleeding & no need for blood suction, 2 grade represent slight bleeding & sometimes blood has to be suctioned, 3 grade represent slight bleeding & blood has to be often suctioned (operative field was clear for few seconds after suction), 4 grade represent average bleeding & blood has to be frequent suctioned (operative field was clearly visible immediately after suction), 5 grade represent massive bleeding& regular blood suction required ( continuous non stopped bleeding that may be faster than suction and required another suction and multiple gauze ; hence surgical field became more obscured and non‐visible that made the operation was so hard and may be difficult). ; ‐ Time to first postoperative rescue analgesic request. ; ‐ Total analgesic consumption in the first 24 h postoperatively was recorded. ; ‐ Incidence of complications including postoperative nausea and vomiting (PONV), dizziness, somnolence, visual disturbance, headache, urine retention, hypotension, bradycardia, confusion, and sedation (assessed on a four‐point scale where 0 = alert, 1 = quietly awake, 2 = asleep but easily aroused, and 3 = deep sleep) were recorded during first 24 hours postoperatively. ; INCLUSION CRITERIA: Patients included in our research were that enrolled for DCR operation with limited age between 25‐60 years old and had American Society of Anesthesiologist physical status of I and II.