A study comparing two herbal medicines for knee pain and stiffness relief

INTERVENTION: CONDITION: Health Condition 1: M170‐ Bilateral primary osteoarthritis of knee PRIMARY OUTCOME: Change in knee joint pain, stiffness and physical function assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)Timepoint: Baseline, Week 4, Week 8, Week 12 and Week 16 SECONDARY OUTCOME: Change in inflammatory markers Erythrocyte Sedimentation Rate (ESR) and C reactive Protein (CRP)Timepoint: Baseline and Week 12 Change in knee joint pain intensity measured using the Visual Analogue Scale (VAS)Timepoint: Baseline, Week 4, Week 8, Week 12 and Week 16 Change in knee joint range of motion assessed by goniometryTimepoint: Baseline, Week 4, Week 8, Week 12 and Week 16 Safety and tolerability assessed by monitoring of adverse events and laboratory parameters including Complete Blood Count, Liver Function Tests and Kidney Function TestsTimepoint: Baseline and Week 12 INCLUSION CRITERIA: 1. Adults of either gender between 30 and 70 years of age. 2. Patients presenting with chronic knee joint pain and stiffness of at least 3 months duration, aggravated by walking, bending or occupational activity, with radiological evidence of knee joint degeneration on X‐ray knee Grade 1 and Grade 2.