Effect of remimazolam bridging or sevoflurane-maintained deep anesthesia extubation on extubation quality after sevoflurane combined with remifentanil anesthesia

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Group SE:Sevoflurane inhalation;Group RE:Remimazolam infusion; CONDITION: Patients undergoing laparoscopic cholecystectomy under general anesthesia with endotracheal intubation. PRIMARY OUTCOME: The number and percentage of patients with an extubation quality score >2; SECONDARY OUTCOME: The intraoperative dosage of vecuronium and remifentanil;The incidence and severity of cough during extubation;Patient demographics;Recovery time;The quality of recovery at 24 hours postoperatively;The number of patients who received cardiovascular active drugs, sufentanil, propofol, or metoclopramide during the period from the end of surgery to departure from the operating room;Complications from the end of surgery to operating room discharge;The number and proportion of patients with each extubation quality score grade;The highest sedation score recorded from the time of recovery to departure from the operating room;Surgical duration;The incidence of sore throat, vocal cord paralysis, arytenoid cartilage dislocation, hoarseness, dysphagia, odynophagia, and postoperative nausea and vomiting (PONV) at 24 hours after surgery;Heart rate (HR), mean arterial pressure (MAP), and peripheral oxygen saturation (SpO?) were recorded at the following time points.;Eye‐opening time;The incidence of recurrent agitation following extubation;The incidence of emergence agitation;Patient recall during anesthesia and the recovery period;The highest VAS pain score recorded from the time of recovery to departure from the operating room;Extubation time;Total hospital stay;The placement status of drainage tubes and urinary catheters; INCLUSION CRITERIA: 1.Patients with ASA physical status I–II, aged >18 years, who required laparoscopic cholecystectomy under general anesthesia with endotracheal intubation.
Epistemonikos ID: 83c364b29e0bfcc35e4adbbfa6786cf91e82209d
First added on: Oct 08, 2026