NVTIA® Ergothioneine for Healthy Aging and Skin Health

Healthy aging has become an important public health objective because of the increasingglobal aging population. Aging is associated with progressive accumulation of oxidativestress, chronic low‐grade inflammation, and gradual decline in cellular function. Thesebiological changes contribute to deterioration of skin condition, reduced physiologicalresilience, and increased susceptibility to age‐related disorders.NVTIA® Ergothioneine is a branded ergothioneine ingredient manufactured understandardized production conditions and intended for use as a dietary supplementingredient. Ergothioneine is a naturally occurring sulfur‐containing amino acidderivative that is actively transported into human tissues through the Organic CationTransporter Novel Type 1 (OCTN1), allowing preferential accumulation in tissues exposedto oxidative stress. Experimental studies have demonstrated antioxidant, cytoprotective,and anti‐inflammatory properties of ergothioneine, suggesting its potential role insupporting healthy aging.Although preclinical and observational studies have suggested potential health benefitsof ergothioneine, well‐designed randomized controlled clinical trials evaluating theeffects of a standardized branded ergothioneine ingredient on healthy aging biomarkersremain limited.The present study is designed to generate high‐quality clinical evidence regarding theeffects of NVTIA® Ergothioneine supplementation on biomarkers associated with healthyaging and skin health in healthy adults. The findings are expected to support scientificunderstanding of ergothioneine supplementation and provide evidence for the use of NVTIA®Ergothioneine as a standardized dietary supplement ingredient.