The effect of red wine consumption on Cytochrome P450 metabolites of arachidonic acid

INTERVENTION: Men who drink 40g of alcohol/day will be invited to participate in a 12 week trial of randomized block design, during which they will substitute the alcohol they drink for either 375 mol of water, or the equvalent volume of de‐alcoholised red wine or red wine each for 4 weeks in crossover design without washout periods. CONDITION: Alcohol and polyphenol consumption on Cytochrome P450 metabolites PRIMARY OUTCOME: Changes in ambulatory Blood pressure. between the treatments Changes in Cytochrome P450 metabolites of Arachidonic acid in urine, plasma, cell membranes. between the treatments will be assessed using gas chromatography mass spectrometry SECONDARY OUTCOME: Plasma Resolvins Plasma and urinary F2‐isoprostanes measured using gas chromatography mass spectrometry INCLUSION CRITERIA: alcohol consumption >30g/day<110g/day, non‐smokers, not taking medication