Evaluation of survival and treatment toxicity with high-dose rate brachytherapy with cobalt 60 in carcinoma of cervix

Purpose: Cervical cancer remains to be a major health problem and cancer-related cause of death among women in developing countries such as Iran where the most cases are diagnosed in locally advanced stage. This cross sectional-analytic study aims to report outcome 154 patients with carcinoma of cervix were treated with external beam radiation therapy (EBRT) and highdose rate (HDR) brachytherapy with cobalt 60 (Co-6o) remote after loading system. Methods and Materials: A total of 154 patients with the international federation of gynecologist and oncologist (FIGO) Stages I-IVA with histopathologically confirmed carcinoma of cervix, followed by the radiation-oncology ward of Shohada-e- Tajrish Hospital in Tehran, Iran, between February 2008 and March 2015. They were completed their scheduled EBRT and HDR brachytherapy with Co-60 remote after loading system. Out of this, 132 patients completed their standard follow up protocol. They were analyzed for three-year disease-free survival (DFS), three-year overall survival (OS) incidence of acute and late complications for HDR brachytherapy. Results: Fourteen patients (9.1 %) were in Stage I (FIGO classification), 8 (5.2%) were in Stage IIA, 26 (16.9%) were in Stage IIB, 100 (64.9%) were in Stage III, and 6 (3.9 %) were in Stage IVA. The follow up duration was between 6 - 60 months with a median of 38 months. Overall rectal and bladder treatment toxicity rates were 33.7%. The three-year DFS rate was 85.7%, 70.7 %, 41% and 16.6% for Stages I, II, III, IVA respectively. Favourable prognostic factors in univariate and multivariate analysis were early stage, tumour size < 4 cm (after adjusting for the residual disease after radiation), no pelvic lymph node involvement and one week gap between EBRT and HDR brachytherapy in three-year DFS (p = 0.001, p = 0.012, p = 0.005, p = 0.005 respectively). The three-year OS rate was 85.7%, 76.4%, 42%, and 33.3% for Stages I, II, III, and IVA, respectively. Favourable prognostic factors in univariate and multivariate analysis were early stage, tumour size < 4 cm, no pelvic lymph node involvement, one week gap between EBRT and HDR brachytherapy and no distant metastasis (during the follow up) in three-year OS (p = 0.001, p = 0.002, p = 0.002, p = 0.002, p = 0.001 respectively). Conclusions: HDR brachytherapy with Co-60 remote after loading system was successful and it showed HDR brachytherapy in treating patients with carcinoma of cervix was effective after EBRT with acceptable rectal and bladder complications.