Study for effectiveness of Nigella sativa (Black seed) in patients with dyspepsia

INTERVENTION: 1g of Nigella sativa seeds powder in capsule + 40mg omeprazole 2g of Nigella sativa seeds powder in capsule + 40mg omeprazole 3g of Nigella sativa seeds powder in capsule + 40mg omeprazole Intervention 1: Triple therapy (clarithromycin+amoxicillin+omeprazole). Intervention 2: 1g of Nigella sativa seeds powder in capsule + 40mg omeprazole. Intervention 3: 2g of Nigella sativa seeds powder in capsule + 40mg omeprazole. Intervention 4: 3g of Nigella sativa seeds powder in capsule + 40mg omeprazole. Treatment ‐ Drugs Triple therapy (clarithromycin+amoxicillin+omeprazole) CONDITION: Dyspepsia Non‐ulcer dyspepsia. ; Dyspepsia PRIMARY OUTCOME: Eradication of H. pylori. Timepoint: 4 weeks after the end of treatment. Method of measurement: Negative stool antigen by rapid monoclonal immunochromatographic method (ImmunoCard STAT! HpSA, Meridian Bioscience Europe). SECONDARY OUTCOME: Improvment in dyspeptic symptoms (epigastric pain and reflux symptoms). Timepoint: 4 weeks after end of teatment. Method of measurement: Questionnaire. INCLUSION CRITERIA: INCLUSION CRITERIA: 1) Patients complaining of dyspeptic symptoms 2) Patients with positive result for H. pylori infection confirmed by both histopathology and rapid urease test (CLO test) Exclusion criteria: 1) the endoscopy showed peptic ulcer, gastric cancer or other gastrointestinal bleeding 2) they had taken proton‐pump inhibitors, bismuth or antibiotics in the last 4 weeks before endoscopy 3) pregnant or lactating 4) intolerant to therapeutic regimens