Anti-inflammatory effect of N-(trifluoromethylphenyl)-2-cyano-3-hydroxy-crotonic acid amide and Gluconic acid on Allergic Rhinitis and Asthma controlling

Allergic rhinitis and asthma are main airway disease with a higher prevalence. Eosinophilic inflammation, airway hyper-responsiveness, mucus hyper-secretion, and reversible airflow obstruction are immunopathogenesis symptoms of rhinitis and asthma. Crotonic acid has bioactivity on the inflammation and Gluconic acid as chelator may protect crotonic acid activity in airway and with together may control allergic rhinitis and asthma. Allergic rhinitis and asthma mice were treated with crotonic and gluconic acid. At least, total IgE, histamine, IL-4, IL-5, and IL-13 levels were measured. In lung tissues, goblet cell hyperplasia, mucus hyper-secretion, and inflammation were evaluated. The level of IL-5, Goblet cell hyperplasia, perivascular and peribronchial inflammation were controlled by crotonic in asthma and allergic rhinitis groups. But total IgE, histamine, IL-4, IL-13 levels and Mucus hyper-secretion had no significant chenges between treated and non-treated asthma and rhinitis groups. Crotonic acid can control eosinophilic inflammation via harnessing of IL-5 and prevent goblet cell hyperplasia. When it was used with gluconic acid, had strong effect on control of allergic rhinis and asthma immunopathology.