Randomized Trial of Multiplex real-time PCR-based antibiotic therapy for severe bloodstream infections

INTERVENTION: 1) Intervention 1 Antibiotic therapy based on the microorganism identification by conventional method and Filmarray system 2) Intervention 2 Antibiotic therapy based on the microorganism identification by conventional method and Verigene system 3) Control Antibiotic therapy based on the microorganism identification by conventional method CONDITION: bacteremia PRIMARY OUTCOME: Duration between the identification of positive blood cultures and the initiation of appropriate antibiotic therapy. SECONDARY OUTCOME: 1) 28 day‐mortality; 2) Duration of ICU stay; 3) Duration of hospital stay; 4) Total cost of antimicrobial agents INCLUSION CRITERIA: