The efficacy of L-Cartin for chronic fatigue syndrome

INTERVENTION: L‐Cartine FF 10 % (Otsuka Pharmacy, Co.LTD., Japan), 2000 mg / day, 8 weeks CONDITION: Chronic fatigue syndrome PRIMARY OUTCOME: Chalder Fatigue Scale,Performance; Status, Fatigue sensation : Visual Analog Scale SECONDARY OUTCOME: CES‐D, POMS, Autonomic nervous system, Carnitine, Ammonia, arithmetic task, d‐ROMs, BAP, sleep‐wake cycle, near infrared spectrometer INCLUSION CRITERIA: Chronic fatigue syndrome (CFS) patients who visit Osaka City University Hospitals, Fatigue Clinical Center and are eligible for the following criteria. (1) Patients fulfilling the CFS criteria determined by CDC (1994) (2) Patients whose diseases duration are more than 6 months and less than 15 years (3) Patients whose fatigue related performances status are equal or less than 3 (4) Patients who are less than 60 year‐old and non‐smokers at the time of getting the informed consent (5) Patients whose body mass index are equal or more than 16 and equal and less than 30 at the time of getting the informed consent (6) Patients who are capable of understanding the study, and those who can give written informed consents