Isolated Intracranial Hypertension Following Coronavirus Disease in 2019 AstraZeneca Vaccine: Report of 2 Consecutive Cases

Herein reported are two patients that developed symptoms of isolated intracranial hypertension (IIH) following vaccination with AstraZeneca ChAdOx1-S vaccine. Patient identified during daily practice and selected for further evaluation for headache based on clinical findings. Both patients underwent diagnostic lumbar puncture, and after detection of high cerebrospinal fluid (CSF) opening pressure, therapeutic CSF extraction was performed. Although causative relationship couldnt be inferred between AstraZeneca ChAdOx1-S vaccine and IIH, solely based on these two cases, all clinicians should be vigilant about IIH in recipients of this vaccine.