The effect of metformine on the uteroplacental circulation in comparison with Aspirin in pregnant women with poly cystic ovary syndrome

INTERVENTION: After uterine artery doppler 50% of control group received placebo similar to metformin 1 tablet BD, 50% of control group received placebo similar to aspirin 1 tablet daily until delivery Aspirin, oral Tab, 80 mg daily until delivery Intervention 1: Metformine, oral Tab, 2000 mg Daily until delivery. Intervention 2: Aspirin, oral Tab, 80 mg daily until delivery. Intervention 3: After uterine artery doppler 50% of control group received placebo similar to metformin 1 tablet BD, 50% of control group received placebo similar to aspirin 1 tablet daily until delivery. Metformine, oral Tab, 2000 mg Daily until delivery Placebo Treatment ‐ Drugs CONDITION: Polycystic ovarian syndrome Uteroplcental circulation and complication of pregnancy. ; Polycystic ovarian syndrome PRIMARY OUTCOME: Uteroplcental circulation. Timepoint: At 12th week of gestational age (before intervention) and 8 weeks after intervention. Method of measurement: Uterine Artery Doppler Ultrasound. SECONDARY OUTCOME: Gestational Diabet. Timepoint: at 24‐28 weeks of pregnancy. Method of measurement: GCT. Preeclampsia. Timepoint: Monthly routine control of pregnancy. Method of measurement: Evaluation of BP and urine protein exam. Preterm labour. Timepoint: After Delivery. Method of measurement: Termination of pregnancy before 37th gestational age. Rate of IUGR. Timepoint: After Delivery. Method of measurement: weight below the 10th percentile for gestational age after Delivery. INCLUSION CRITERIA: INCLUSION CRITERIA: PCOS diagnosis before pregnancy was based on the presence of poly cystic ovaries verified by ultrasonography and oligomenorea (length of menstrual cycle more than 35 days or hirsutism, gestational age 5‐12 weeks, single live fetus, pregnant women between 18‐40years and Exclusion criteria: Inability to follow up