Is abnormal brain insulin action implicated in the biology of depression? A pilot neuroimaging study in adolescents

Authors
Category Primary study
JournalNeuropsychopharmacology
Year 2026
Brain insulin action was measured in adolescents with (cases) and without (controls) depression, by calculating the difference in resting-state functional connectivity (ΔrsFC) following an intranasal insulin challenge. A significant Group × Condition interaction effect was identified: controls exhibited greater ΔrsFC with intranasal insulin compared to cases in brain regions regulating cognitive/emotional processing.
Epistemonikos ID: 7e9801adc61971189bbc55ae570c2057be3f4d8b
First added on: Sep 19, 2026