Chronos: Can the antidepressive response induced by sleep deprivation (wake-therapy) be sustained through continuous stabilisation of the diurnal rhythm and long term light treatment in patients with major depression treated with duloxetine?

INTERVENTION: Trade Name: Cymbalta Product Name: Duloxetine Pharmaceutical Form: Capsule, soft CONDITION: Major depression PRIMARY OUTCOME: Main Objective: The primary objective of the present study is to examine whether the combination of duloxetine and chronoterapeutic methods induces higher remission and response rates at an earlier time point. Primary end point(s): Study completed (29 weeks); Compliance of drug less than 85%; Compliance with visits less than 85%; Eligibility violations ; Severe adverse events Secondary Objective: INCLUSION CRITERIA: A diagnosis of major depression according to DSM‐IV Age of 18 or above A score on the Hamilton Depression Scale,17 items version of at least 18 Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range