Manchester vascular access study

INTERVENTION: Extra bloods at baseline: Patients will have an extra blood test at this point for haematological/biochemical parameters and DNA/stem cell sampling and analysis. Extra blood tests will be optional and will not be mandatory for all participating centres. Perioperatively ‐ blood tests, patients will undergo further blood tests peri‐operatively and these will be linked to their peri‐operative clinically indicated blood tests; blood tests will be optional and are not mandatory for study inclusion. US scan ‐ follow‐up, Doppler ultrasound scan will be used to assess maturation. It is anticipated that most patients will have two extra visits with tests during their visits (routine postoperative visit and scan at 6 weeks is standard clinical practice). For the minority of patients who have not used their fistula by 6 months, we will perform the final study evaluation with US at 6 months. CONDITION: Topic: Renal disorders; Subtopic: Renal disorders; Disease: All Renal disorders ; Urological and Genital Diseases PRIMARY OUTCOME: Successful (unassisted) maturation defined as either A or B; A: Use of the AVF with two needles SECONDARY OUTCOME: Not provided at time of registration INCLUSION CRITERIA: 1. The participant is in need of AV dialysis access for haemodialysis. 2. Participant is available and can return for follow‐up visits Target Gender: Male & Female ; Lower Age Limit 18 years