Improving sleep and quality of life in patients with idiopathic interstitial pneumonia, using nocturnal supplemental oxygen

INTERVENTION: Oxygen (2 litres/min) via nasal cannulae from a concentrator during sleep (approximately 6 to 8 hours per 24 hours), every night for 4 weeks, with an overnight sleep study on day 28. Subjects then have a two week washout period and crossover to receive the sham intervention, as below, for a further 4 weeks, and then another sleep study on day 70. Note: the order of these two arms will be random so as to ensure blinding for subjects and investigators. CONDITION: Idiopathic interstitial pneumonia Interstitial lung disease PRIMARY OUTCOME: The primary outcome in this study is the total sleep time with SpO2 below 90%. SECONDARY OUTCOME: Apnoea‐Hypopnoea Index Arousal index Differences in Six minute walk distance (measured in metres) Oxygen desaturation index Pittsburgh Sleep Quality Index Quality of life questionnaire: St George's Respiratory Questionnaire Quality of life questionnaire: University of California, San Diego Shortness of Breath Questionnaire Sleep architecture (% slow wave, REM and transitional sleep) INCLUSION CRITERIA: Patients 18 ‐ 80 yrs. Patients able to perform a polysomnogram (sleep study), as determined following clinical assessment. Patients with nocturnal hypoxaemia, defined as >10% of the night with SpO2 <90% on overnight oximetry or PSG Patients able to give informed consent. Patients with idiopathic interstitial pneumonia (IIP), according to American Thoracic Society /European Respiratory Society criteria. Absence of daytime resting hypoxaemia (ie with PaO2 > 55mmHg).