The efficacy of nalgesic (curcumin) in the treatment

INTERVENTION: We aim to recruit 10 volunteers who have the clinical diagnosis of (OsteoArthritis)OA of the thumb joint to enter a double blinded, placebo controlled study of Curcumin (Nalgesic) with three (single dose) oral administration (tablet) conditions (placebo, normal dose ‐ 1200mg, and double dose 2400mg). This is a cross‐over trial. All participants receive all the interventions in different sequences during the study. They act as their own control. There is a full 7 day period between treatments to ensure washout of the trial drug. The trial will be conducted over three consecutive week‐ends (Saturdays). CONDITION: Osteoarthritis PRIMARY OUTCOME: Pain reduction as measured by subjective self‐report using a visual analog scale SECONDARY OUTCOME: Grip strength as measured using a pinchmeter Range of movement as measured using a goniometer in two ways: abduction and extension of the thumb INCLUSION CRITERIA: Diagnosis of OA of the thumb by a rheumatologist (Dr Daniel Lewis).