Identification of the autoantigen of celiac disease.

Category Primary study
JournalAnnals of the New York Academy of Sciences
Year 1998
Tissue transglutaminase is demonstrated to be the unknown endomysial autoantigen by means of immunoprecipitations from a fibrosarcoma cell culture. A novel hypothesis for the pathogenesis of celiac disease is formulated: The mainly intracellular tissue transglutaminase is released from cells during wound healing where it aids in stabilizing the wound area by cross-linking a small set of extracellular matrix components.
Epistemonikos ID: 7cc0248d4c4cfe610d06e44dc67093c0f7a647d2
First added on: Apr 19, 2022