Clozapine versus chlorpromazine for the treatment of schizophrenia: Preliminary results from a double-blind study.

Authors
Category Primary study
JournalThe Journal of clinical psychiatry
Year 1979
Fifteen schizophrenic inpatients were treated in a double-blind comparison study of clozapine versus chlorpromazine. Clozapine appeared to be at least as effective as chlorpromazine without producing any extrapyramidal reactions. Although bone marrow toxicity associated with clozapine has led to the drug's withdrawal from clinical use, data from studies of clozapine demonstrate that a drug can be effective antipsychotic without producing neurologic reactions.
Epistemonikos ID: 7cb6e5d2d493a2a2cce02ae0111a4a9d1b1ff182
First added on: Dec 24, 2012