NCT00230971- A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection

This reference is based in information reported in a registry and results database of clinical studies. It has been prepared by collaborators of Epistemonikos. POPULATION: 467 participants; Men and women aged 18 or older with a) Clinical diagnosis of complicated intra-abdominal infection that requires surgery within 24 hours. b) Fever plus other symptoms such as nausea, vomiting, abdominal pain. COMPARISONS: 1. Tigecycline every 12 hours IV (an initial dose of 100 mg followed by 50 mg every 12 hours). 2. Ceftriaxone sodium 2 g once daily intravenously plus metronidazole 1 g to 2 g daily given in divided doses intravenously. For a minimum of 4 days and up to 14 days at the discretion of the investigator.