The effects of 1L infusions of 0.9% saline and Voluven® on plasma volume, serum biochemistry and sodium and water controlling hormones in healthy volunteers: a double blind, randomised crossover study

INTERVENTION: Double blind, randomised crossover study CONDITION: Effects of Voluven® infusion on plasma volume, serum biochemistry and sodium and water controlling hormones ; Not Applicable PRIMARY OUTCOME: Difference in effects produced by the two infusions on haemotocrit, serum albumin, chloride, osmolality, AVP, renin, ANP and aldosterone. Differences betwen the infusions will be tested for statistical significance using the Wilcoxon signed ranks test and repeated measures ANOVA. Differences will be considered significant if P<0.05. SECONDARY OUTCOME: Not provided at time of registration INCLUSION CRITERIA: Male subjects aged between 18 and 40 years responding to local advertisement will be screened by questionnaire and medical examination before being chosen.