Does progesterone given as luteal phase support and amoxycillin as cervical mucus enhancer increase the likelihood of pregnancy in subfertile women receiving clomiphene citrate for anovulation?

INTERVENTION: Arm 1: Periovulatory placebo (one orally three times daily) days 11‐16 AND progesterone pessaries (400 mg vaginally at night) during each luteal phase (used for 10 consecutive nights) for up to 8 cycles OR Arm 2: Periovulatory amoxycillin (500mg orally three times daily) days 11‐16 AND progesterone pessaries (400 mg vaginally at night) during each luteal phase (used for 10 consecutive nights) for up to 8 cycles All participants will be instructed in the Sympto‐Thermal Method. All participants will be administered Clomiphene citrate orally (+/‐ metformin orally) at a dose necessary to induce ovulation CONDITION: Anovulation Subfertility PRIMARY OUTCOME: Positive pregnancy test. ; ; This is defined as HCG > 25 mIU/L. This test is either a quantitative serum level or a qualitative urine point of care test (which becomes positive at a level of 25 mIU/L). SECONDARY OUTCOME: Acceptability of intervention ‐ by completion of an acceptability survey tool Congenital anomalies Cost effectiveness ‐ looking at time, resources, medications, clinical setting costs DASS 21 Scores ‐ screening for depression, anxiety and stress Gestation and weight at birth Live birth rate Maternal morbidity composite ‐ to include antepartum haemorrhage, gestational hypertension, pre‐eclampsia, gestational diabetes, venothrombo‐embolism, postnatal depression Miscarriage rate Neonatal morbidity composite ‐ nursery admission (for any reason and including intraventricular haemorrhage, necrotising enterocolitis, respiratory distress syndrome) Time to conception INCLUSION CRITERIA: 1. Anovulation (based on prolonged and hormonally quiescent 'cycles') AND A. Failing to achieve a pregnancy after 12 months of unprotected random intercourse OR B. Failing to achieve an ongoing pregnancy (greater than 20 weeks) after 12 months of unprotected random intercourse OR C. A history of 3 or more miscarriages