Fluproquazone: Analgesic activity in outpatients with non-migrainous headache

The analgesic activity of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(HI)-quinazolinone (fluproquazone) was investigated in three separate controlled studies including 131 outpatients with non-migrainous headache. By means of the patients' self-assessment of pain intensity and pain relief, 25 mg and 50 mg doses were shown to be effective according to some parameters of analgesic effect; a 100-mg dose was more effective, being significantly different from placebo for all parameters of analgesia. Fluproquazone 50 mg was as active as acetylsalicylic acid 1000 mg and slightly less active than a combination of propyphenazone 220 mg and allobarbital 30 mg. Except for the occurrence of vomitting in one patient after fluproquazone 50 mg and 100 mg, the drug was well tolerated.