Neural mechanism of impulse control on addiction by tDCS and a cognitive neuroscience approach

INTERVENTION: Anodal stimulation of the left DLPFC: The anode place at the left DLPFC and cathode placed at the right DLPFC, stimulated by tDCS. A constant current of 2mA intensity, provided by battery, was applied for 20 minutes. Stimulation with 2 mA for a single session per day. Total 10 sessions for 10 days. Anodal stimulation of the right DLPFC: The anode place at the right DLPFC and cathode placed at the left DLPFC, stimulated by tDCS. A constant current of 2mA intensity, provided by battery, was applied for 20 minutes. Stimulation with 2 mA for a single session per day. Total 10 sessions for 10 days. Sham stimulation of DLPFC: electrodes placed at the bilateral DLPFC as active groups, which anode at right DLPFC in half of participants and anode at left DLPFC in another half of participants but turned off after 30 seconds of stimulation. A constant current of 2mA intensity, provided by battery, but turned off after 30 seconds of stimulation.Total 10 sessions for 10 days CONDITION: A treatment option for substance dependence PRIMARY OUTCOME: BZD dependence self report questionnaire for craving of Zolpidem; Fagerstrom Test for Nicotine Dependence (FTND) for Nicotine dependence; Visual analogue scale (VAS);Depression and somatic symptoms scale (DSSS); SECONDARY OUTCOME: Nerocognitive testings will be also performed three times, baseline, Day 5 and 2 weeks post‐treatment Go/no‐go back; CANTAB INCLUSION CRITERIA: (1) Meet the Structured Clinical Interview for DSM‐IV(SCID)criteria for Zolpidem/Nicotine dependence, and the duration over one year (2) Evaluate the comorbidity by MINI interview