A study on the effectiveness of core mindfulness skills combined with insomnia cognitive behavioral therapy for patients with depression and insomnia, as well as the role of the gut microbiota

INTERVENTION: Intervention group:Core mindfulness skills in conjunction with the CBTI treatment program;Control group:Standard CBTI treatment plan; CONDITION: Depression with Insomnia PRIMARY OUTCOME: Insomnia Severity Index scale;Patient health questionnaire; SECONDARY OUTCOME: Perceived Stressscale‐10;Mindful Attention Awareness Scale; INCLUSION CRITERIA: (1) Aged >= 18 years; (2) Meeting the criteria for insomnia disorder :1) difficulty initiating and/or maintaining sleep, with a sleep latency greater than or equal to 30 minutes and a sleep duration less than or equal to 6.5 hours; 2) insomnia at least 3 times per week for more than 3 months; 3) Accompanied by daytime functional impairment as follows: Fatigue or general discomfort, difficulty concentrating, impaired ability to maintain attention or memory, decreased learning efficiency, work ability and/or social function, decreased emotional stability or irritability, daytime sleepiness, decreased interest or lack of energy, increased tendency to make errors in work or driving and easy to be nervous. Somatic symptoms such as headache, dizziness or other physical discomfort related to lack of sleep, and excessive concern about their own sleep status; (3) Meeting the criteria for depressive disorder: 1) At least one core symptom (significant low mood, loss of i